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The ontogeny of behavioral sensitization to phencyclidine

✍ Scribed by Frank M. Scalzo; R.Robert Holson

Book ID: 113387435
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 715 KB
Volume: 14
Category: Article
ISSN: 0892-0362
DOI: 10.1016/0892-0362(92)90023-4

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In this study, we tested the hypothesis that chronic administration of phencyclidine (PCP), an N-methyl-D-aspartate (NMDA) receptor antagonist, would cause a long-lasting behavioral sensitization associated with neuronal toxicity. Female Sprague-Dawley rats were administered PCP (20 mg/kg, i.p.) onc