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The Occluding Loop in Cathepsin B Defines the pH Dependence of Inhibition by Its Propeptide †

✍ Scribed by Quraishi, Omar; Nägler, Dorit K.; Fox, Ted; Sivaraman, J.; Cygler, Miroslaw; Mort, John S.; Storer, Andrew C.

Book ID
121365825
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
89 KB
Volume
38
Category
Article
ISSN
0006-2960

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Potent and selective cathepsin B inhibitors have previously been synthesized based upon the natural product cysteine protease inhibitor E-64. X-ray crystal data indicates that these compounds interact through their free carboxylate with the positively charged histidine residues located on the prime-