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The O-neophyl rearrangement of 1,1-diarylalkoxyl radicals. Experimental evidence for the formation of an intermediate 1-oxaspiro[2,5]octadienyl radical

✍ Scribed by Massimo Bietti; Alessandra Calcagni; Daniel Oscar Cicero; Roberto Martella; Michela Salamone


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
329 KB
Volume
51
Category
Article
ISSN
0040-4039

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An excellent substrate of methylmalonyl-CoA mutase, methylmalonyl-carba-(dethia) coenzyme A (methylmalonyl-CH(2)-CoA), was synthesized by a chemoenzymatic method and its alpha-proton was exchanged with deuterium by long-term incubation in deuterium oxide at pH 6.9. After addition of highly purified