## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The ‘O-acyl isopeptide method’ for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid β peptide (Aβ) 1–42
✍ Scribed by Youhei Sohma; Yoshio Hayashi; Maiko Kimura; Yousuke Chiyomori; Atsuhiko Taniguchi; Masato Sasaki; Tooru Kimura; Professor Yoshiaki Kiso
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 226 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.649
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## Abstract A novel strategy for a more efficient synthesis of difficult sequence‐containing peptides, the __S__‐acyl isopeptide method, was developed and successfully applied. A model pentapeptide Ac–Val–Val–Cys–Val–Val–NH~2~ was synthesized via its water‐soluble __S__‐acyl isopeptide using an __S
## Abstract ‘__O__‐Acyl isopeptide method’ is an efficient synthetic method for peptides. We designed ‘__O__‐acyl isodipeptide units’, Boc‐Ser/Thr(Fmoc‐Xaa)‐OH, as important building blocks to enable routine use of the __O__‐acyl isopeptide method. In the synthesis of an Aβ1–42 isopeptide using __O