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Ab initio model studies of copper binding to peptides containing a His–His sequence: relevance to the β-amyloid peptide of Alzheimer’s disease

✍ Scribed by Duilio F. Raffa; Rodolfo Gómez-Balderas; Patrick Brunelle; Gail A. Rickard; Arvi Rauk


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
868 KB
Volume
10
Category
Article
ISSN
1432-1327

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## Abstract Amyloid‐β peptide (Aβ) is the principal constituent of plaques associated with Alzheimer's disease (AD) and is thought to be responsible for the neurotoxicity associated with the disease. Copper binding to Aβ has been hypothesized to play an important role in the neruotoxicity of Aβ and