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The Novel Potent Multidrug Resistance Inhibitors N,N-bis(cyclohexanol)amine Aryl Esters Are Devoid of Vascular Effects

✍ Scribed by Saponara, Simona; Gorelli, Beatrice; Tzankova, Virginia; Martelli, Cecilia; Teodori, Elisabetta; Sgaragli, Giampietro; Fusi, Fabio


Book ID
120551904
Publisher
S. Karger AG
Year
2011
Tongue
English
Weight
210 KB
Volume
88
Category
Article
ISSN
0031-7012

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Conformational modulation of the aryl portion of a set of N,N-bis(cyclohexanol)amine aryl esters (1a-d) that are potent Pgp-dependent MDR inhibitors has been performed. Toward this end the trans-3-(3,4,5-trimethoxyphenyl)acrylic acid present in set 1 was substituted with 3-(3,4,5-trimethoxyphenyl)pr