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N , N -bis(Cyclohexanol)amine Aryl Esters: A New Class of Highly Potent Transporter-Dependent Multidrug Resistance Inhibitors

✍ Scribed by Martelli, Cecilia; Alderighi, Daniela; Coronnello, Marcella; Dei, Silvia; Frosini, Maria; Le Bozec, Bénédicte; Manetti, Dina; Neri, Annalisa; Romanelli, Maria Novella; Salerno, Milena; Scapecchi, Serena; Mini, Enrico; Sgaragli, Giampietro; Teodori, Elisabetta


Book ID
120550921
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
760 KB
Volume
52
Category
Article
ISSN
0022-2623

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Conformational modulation of the aryl portion of a set of N,N-bis(cyclohexanol)amine aryl esters (1a-d) that are potent Pgp-dependent MDR inhibitors has been performed. Toward this end the trans-3-(3,4,5-trimethoxyphenyl)acrylic acid present in set 1 was substituted with 3-(3,4,5-trimethoxyphenyl)pr