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The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents

✍ Scribed by Zrinka Rajić; Dimitra Hadjipavlou-Litina; Eleni Pontiki; Marijeta Kralj; Lidija Šuman; Branka Zorc


Book ID
111368829
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
283 KB
Volume
75
Category
Article
ISSN
1747-0277

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Design, synthesis and biological evaluat
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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical