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Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors

โœ Scribed by Li, Yingjun; Yu, Yang; Jin, Kun; Gao, Lixin; Luo, Tongchuan; Sheng, Li; Shao, Xin; Li, Jia


Book ID
127170994
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
600 KB
Volume
24
Category
Article
ISSN
0960-894X

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The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their in