𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

✍ Scribed by Sergio Valente; Emilie Bana; Elodie Viry; Denyse Bagrel; Gilbert Kirsch

Book ID
104004725
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
458 KB
Volume
20
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.

✦ Synopsis

The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.

πŸ“œ SIMILAR VOLUMES

Synthesis and Biological Evaluation of D
Synthesis and Biological Evaluation of Dialkylsubstituted Maleic Anhydrides as Novel Inhibitors of Cdc25 Dual Specificity Phosphatases.
✍ Laurent Brault; Mickael Denance; Estelle Banaszak; Souhayla El Maadidi; Eric Bat πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons βš– 24 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Synthesis and Biological Evaluation of N
Synthesis and Biological Evaluation of Novel Heterocyclic Quinones as Inhibitors of the Dual Specificity Protein Phosphatase CDC25C.
✍ Olivier Lavergne; Anne-Cecile Fernandes; Laetitia Brehu; Alban Sidhu; Marie-Chri πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 42 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.