✦ LIBER ✦

The nonspecific helper effect of mixed lymphocyte reactions on the induction of T cell-mediated immunity in vitro

✍ Scribed by A. Altman; I. R. Cohen

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 465 KB
Volume: 4
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830040811

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✦ Synopsis

Abstract

We compared induction of sensitization in the mixed lymphocyte reaction (MLR) and in a mouse anti‐fibroblast reaction. Our study demonstrated that induction processes in these two reactions, both known to be T cell‐mediated reactions, are governed by different factors. Moreover, these two reactions interact with each other and this interaction is manifested by the ability of a MLR occurring during the sensitization phase of the anti‐fibroblast reaction to enhance specific cytolysis measured during the effector phase. This helper effect appears to be immunologically nonspecific, since it can be obtained by the use of third party, antigenically unrelated lymphocytes as stimulator cells in the MLR.

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