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The no-effect level, an old bone of contention in toxicology

✍ Scribed by Gerhard Zbinden


Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
282 KB
Volume
43
Category
Article
ISSN
0340-5761

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Statistical issues on the determination
✍ Takashi Yanagawa; Yasuki Kikuchi πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 182 KB

## Abstract The determination of a safe exposure level for toxic agents, often defined as the highest dose level with no toxic effect and termed the no‐observed‐adverse‐effect level (NOAEL) is reviewed. The conventional methods based on statistical tests are criticized, particularly when the sample