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Statistical issues on the determination of the no-observed-adverse-effect levels in toxicology

✍ Scribed by Takashi Yanagawa; Yasuki Kikuchi

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 182 KB
Volume: 12
Category: Article
ISSN: 1180-4009
DOI: 10.1002/env.467

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The determination of a safe exposure level for toxic agents, often defined as the highest dose level with no toxic effect and termed the no‐observed‐adverse‐effect level (NOAEL) is reviewed. The conventional methods based on statistical tests are criticized, particularly when the sample size is small, and an alternative method, which is based on the Akaike information criterion (AIC), is discussed. The method is extended to the estimation of the NOAEL for continuous data. Computer programs for Windows 95/NT for determining the NOAEL by the AIC approach are developed and its application to practical data is illustrated with examples. Copyright © 2001 John Wiley & Sons, Ltd.

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