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The Neuronal Cell-Surface Molecule Mitogenic for Schwann Cells is a Heparin-Binding Protein

โœ Scribed by Nancy Ratner, Dingming Hong, Michael A. Lieberman, Richai P. Bunge and Luis Glaser

Book ID
123636074
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
1024 KB
Volume
85
Category
Article
ISSN
0027-8424

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Evidence that the axolemmal mitogen for
Evidence that the axolemmal mitogen for cultured schwann cells is a positively charged, heparan sulfate proteoglycan-bound, heparin-displaceable molecule
โœ Dr. M. A. Decoster; G. H. Devries ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 543 KB

Treatment of axolemma with pH 9 buffer results in a pellet enriched two-fold in the mitogen for cultured Schwann cells. Heparitinase treatment releases 8 % of the mitogen into solution, while heparin selectively solubilizes the mitogen, resulting in an extract which has a specific mitogenic activity