𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The neuroendocrine effects of venlafaxine in healthy subjects

✍ Scribed by C. Daffner-Bugía; G. Laakmann; U. Voderholzer; C. Haag; T. Baghai; S. Kolmsee; U. Schröder; T. Munz

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
591 KB
Volume
11
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Venlafaxine hydrochloride represents a novel chemical class of antidepressant compounds. In preclinical studies it had monoamine uptake inhibitory properties. It specifically inhibited the uptake of serotonin (5-HT) norepinephrine (NE) and dopamine (DA) in rat brain synaptosomes. Previous studies showed that various classes of psychotropic drugs with different effects on central aminergic systems exhibit distinct neuroendocrine profiles. In this study we investigated the effect of ascending doses of venlafaxine (12.5 mg, 25 mg, 50 mg, 75 mg orally) on neuroendocrine function in six healthy male subjects, using a single-blind, placebo-controlled study design. After the ascending doses of venlafaxine there could be demonstrated descriptively an influence on GH, and prolactin after the higher doses of venlafaxine. The cortisol secretion was statistically significantly influenced by venlafaxine, and showed a dosedependent increase. These neuroendocrine effects of venlafaxine may be interpreted as being a result of 5-HT and NE reuptake-inhibition properties of the substance. Evidence for a DA reuptake-inhibition was not found as DAagonists lead to an inhibition of prolactin secretion.

📜 SIMILAR VOLUMES

Mismatch negativity is not correlated wi
Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects
✍ M. Hansenne; E. Pinto; G. Scantamburlo; A. Couvreur; J. Reggers; S. Fuchs; W. Pi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB

## Abstract The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings

Effects of substance P on memory and moo
Effects of substance P on memory and mood in healthy male subjects
✍ Inga Herpfer; Michael Katzev; Bernd Feige; Bernd L. Fiebich; Ulrich Voderholzer; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB 👁 1 views

## Abstract There is evidence from human and animal studies that substance P (SP) is involved in the etiopathology of depression and anxiety. Furthermore, animal studies have shown effects of SP on memory. In a double‐blind, randomized cross‐over study, 13 healthy young men received SP (1.5 pmol/kg

Disposition of zofenopril calcium in hea
Disposition of zofenopril calcium in healthy subjects
✍ Sampat M. Singhvi; James E. Foley; David A. Willard; Richard A. Morrison 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB

Zofenopril calcium (1) is a prodrug that is hydrolyzed in vivo to the active angiotensin-converting enzyme (ACE) inhibitor SQ 26,333 (2). In a two-way crossover study, six healthy male subjects (age range 25-36 years) each received an iv 11.2-mg dose of ['4C]SQ 26,703 (14C-3; the L-arginine salt of