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The Nb rat prostatic adenocarcinoma's dose response to methotrexate and adriamycin

✍ Scribed by Joseph R. Drago; John Palmer

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
243 KB
Volume
24
Category
Article
ISSN
0022-4790

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✦ Synopsis

The Noble rat prostatic adenocarcinonia, Nb-Pr-A.1.-11. an androgeninsensitive tumor. is the sub-ject of this experiment. Dose responses wcre carried out with treatment of these tumors with three doses of adriamycin and two doses of methotrexate. Adriamycin treatment resulted in dccrcased tumor volume and decreased number of metastases in the higher dosage. Methotrexate also decreased metastasis and tumor volume. N o animal treated with either of these agents in this protocol had the tumor undergo complete tumor regression. a criteria used in evaluation of chemotherapies with this animal modcl.

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## Background: The clonally derived rat prostatic epithelial cell line nrp-152 was examined to determine its ability to differentiate in a tissue recombination model. ## Methods: Nrp-152 cells alone, or combined with urogenital mesenchyme (ugm) or 10t1/2 fibroblasts, were grafted beneath the rena