𝔖 Bobbio Scriptorium
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The nature of inactivating lesions produced by platinum (II) complexes in phage λ DNA

✍ Scribed by J. Filipski; K.W. Kohn; W.M. Bonner


Book ID
113136201
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
530 KB
Volume
32
Category
Article
ISSN
0009-2797

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The anticancer drug cisplatin elicits its cytotoxicity through damaging DNA. A sensitive method for following this interaction involves the use of an analog cis-[3H]dichloro(ethylenediamine)platinum(II) (cis-[3H]DEP). Cells are incubated with this analog, the DNA is purified, the enzyme is digested,