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Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)

โœ Scribed by Eastman, Alan

Book ID
126863750
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
859 KB
Volume
22
Category
Article
ISSN
0006-2960

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Analysis and quantitation of the DNA dam
Analysis and quantitation of the DNA damage produced in cells by the cisplatin analog cis-[3H]dichloro(ethylenediamine)platinum(II)
โœ Alan Eastman ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 573 KB

The anticancer drug cisplatin elicits its cytotoxicity through damaging DNA. A sensitive method for following this interaction involves the use of an analog cis-[3H]dichloro(ethylenediamine)platinum(II) (cis-[3H]DEP). Cells are incubated with this analog, the DNA is purified, the enzyme is digested,