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Interstrand crosslinks and sequence specificity in the reaction of cis-dichloro(ethylenediamine)platinum(II) with DNA

✍ Scribed by Eastman, Alan


Book ID
126061209
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
755 KB
Volume
24
Category
Article
ISSN
0006-2960

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Analysis and quantitation of the DNA dam
✍ Alan Eastman πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 573 KB

The anticancer drug cisplatin elicits its cytotoxicity through damaging DNA. A sensitive method for following this interaction involves the use of an analog cis-[3H]dichloro(ethylenediamine)platinum(II) (cis-[3H]DEP). Cells are incubated with this analog, the DNA is purified, the enzyme is digested,