The nature of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated hemopoiesis, colony stimulating factor (CSF) requirement for colony formation, and the effect of TPA on [125I]CSF-1 binding to macrophages

Role of phorbol ester receptors in the 1

Role of phorbol ester receptors in the 12-0-tetradecanoyl-phorbol-13-acetate (TPA)-induced down-regulation of colony-stimulating factor (CSF-1) binding to murine peritoneal exudate macrophages

✍ Ben D.-M. Chen; Kimberly L. Wilkins 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 915 KB

Treatment of murine peritoneal exudate macrophages (PEM) by tumor-prornoting phorbol esters (TPA) results in a rapid loss of binding activity to radioactive-labeled colony-stimulating factor ([1251]-CSF-1) on the cell surface. The inhibitory effect of TPA on PEM i s transient; treated cells recover