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The narrow substrate specificity of human tyrosine aminotransferase – the enzyme deficient in tyrosinemia type II

✍ Scribed by Sharada Sivaraman; Jack F. Kirsch


Book ID
111310501
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
375 KB
Volume
273
Category
Article
ISSN
1432-1327

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The human tyrosine aminotransferase gene
✍ Eva-Maria Westphal; Ernst Natt; Tiemo Grimm; Michel Odievre; Gerd Scherer 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 532 KB

Deficiency in hepatic tyrosine aminotransferase (TAT) causes tyrosinemia type II, an autosomal recessively inherited disorder. Using a TAT cosmid clone, we have identified an MspI restriction fragment length polymorphism (RFLP) 5' to the TAT gene, with allele frequencies of 0.63 and 0.37. Analysis o