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The N-terminal of the estrogen receptor (ERα) mediates transcriptional cross-talk with the retinoic acid receptor in human breast cancer cells

✍ Scribed by Caroline Rousseau; Filippa Pettersson; Marie-Claude Couture; Andre Paquin; Jacques Galipeau; Sylvie Mader; Wilson H. Miller Jr.

Book ID
117668595
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
392 KB
Volume
86
Category
Article
ISSN
0960-0760

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Estrogen receptor-negative breast cancer
Estrogen receptor-negative breast cancer cells transfected with the estrogen receptor exhibit increased RARα gene expression and sensitivity to growth inhibition by retinoic acid
✍ M. Saeed Sheikh; Zhi-Ming Shao; Jian-Chyi Chen; Arif Hussain; Anton M. Jetten; J 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 968 KB

We and others have shown previously that retinoic acid (RA) selectively inhibits the growth of estrogen receptor (ER)-positive human breast carcinoma (HBC) cells and ER-negative cells are refractory to RA inhibition o f growth. The ER-negative cells inherently express lower levels of RARa and retino