๐”– Bobbio Scriptorium
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The mutagenicity to mammalian cells of pyrimidine nucleoside analogs

โœ Scribed by Eliezer Huberman; Charles Heidelberger


Book ID
116036485
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
187 KB
Volume
14
Category
Article
ISSN
0027-5107

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The herpes simplex virus (HSV) thymidine kinase (tk) gene was transfected into Chinese hamster ovary (CHO) 51-1 I glycells to test its effect on the cytotoxic and mutagenic activity of anti-herpetic nucleoside analogues. Insertion of the viral tk was verified by Southern blot analysis, by sensitivit