BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions
โฆ LIBER โฆ
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair
โ Scribed by Lea M Starita; Jeffrey D Parvin
- Book ID
- 114309464
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 122 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0955-0674
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## Abstract The localization of proteins to specific subcellular compartments often reveals clues regarding their biological functions. Although significant progress has been made towards understanding how damaged DNA is repaired, experiments to date have primarily focused on signal transduction pa
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