The multicellular (as opposed to the monoclonal) origin of the murine myeloma cell

✍ Scribed by T.F.C.S. Warner; R.G. Krueger

• Publisher: Elsevier Science
• Year: 1975
• Tongue: English
• Weight: 329 KB
• Volume: 54
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1016/s0022-5193(75)80122-6

✦ Synopsis

We hypothesize that the murine myeloma ceil, which may arise after induction by a number of chemical and physical agents, is the hybrid product of fusion between a plasma cell or its precursor and a macrophage. During the activation and transformation of peritoneal macrophages by mineral oil or other foreign substances, C-type viruses are induced, and these act as fusion factors. Creation of the myeloma cell is achieved by the fusion of a "transformed" macrophage with a B-cell, which had been previously activated by a specific antigen or interaction with an antigen sensitive T-cell, stimulating its differentiation to a plasma cell. 10, 358.