The mucosal milieu creates tolerogenic dendritic cells and TR1 and TH3 regulatory cells
β Scribed by Weiner, Howard L.
- Book ID
- 109831994
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 123 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/90604
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## Abstract The gut is home to a large number of Treg, with both CD4^+^ CD25^+^ Treg and bacterial antigenβspecific Tr1 cells present in normal mouse intestinal lamina propria. It has been shown recently that intestinal mucosal DC are able to induce Foxp3^+^ Treg through production of TGFβΞ² plus re
## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25βdihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low ILβ12 and enhanced ILβ10 secretion