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The monoamine oxidase B gene exhibits significant association to ADHD

✍ Scribed by Jun Li; Yufeng Wang; Songnian Hu; Rulun Zhou; Xiaomin Yu; Bing Wang; Lili Guan; Li Yang; Feng Zhang; Stephen V. Faraone

Book ID
101455900
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
74 KB
Volume
147B
Category
Article
ISSN
1552-4841

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✦ Synopsis

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition with strong genetic basis. Recent work in China indicated that ADHD may be linked to Xp1–2 in the Han Chinese population. The gene encoding monoamine oxidase B (MAOB), the main enzyme degrading dopamine in the human brain, is located in this region. The current study sequenced the exons and the 5β€² and 3β€² flanking regions of the MAOB gene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 3′‐UTR. We assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P = 3.28E‐15; rs1040399, P = 1.87E‐6; 2276T>C or 2327T>C, P = 2.20E‐6) and haplotype‐based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population. Β© 2007 Wiley‐Liss, Inc.

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