The enzyme serum paraoxonase shows a polymorphism in Europeans which is governed by two alleles. The first allele has a gene frequency plow of 0.716-0.777, and is manifested as a low activity group in homozygotes. More than 50% of all European test subjects can be included in this group. A second al
The molecular basis of the human serum paraoxonase activity polymorphism
โ Scribed by Humbert, Richard; Adler, David A.; Disteche, Christine M.; Hassett, Christopher; Omiecinski, Curtis J.; Furlong, Clement E.
- Book ID
- 109914895
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 457 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1061-4036
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๐ SIMILAR VOLUMES
Incubation of the sera of 799 nonrelated persons with paraoxon led to varying degrees of inhibition of the serum cholinesterase (EC 3.1.1.8) with residual activity between 0% and 67.4% of the initial activity. This is the result of a differing paraoxonase (EC 3.1.1.2) activity. The residual activiti
Ideally we would like to treat people exposed to nerve agents with an enzyme that rapidly destroys nerve agents. The enzymes considered for such a role include human butyrylcholinesterase (BChE), acetylcholinesterase (AChE), carboxylesterase and paraoxonase (PON1). Success has been achieved in endow