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The Molecular Basis of Filamin Binding to Integrins and Competition with Talin

✍ Scribed by Tiila Kiema; Yatish Lad; Pengju Jiang; Camilla L. Oxley; Massimiliano Baldassarre; Kate L. Wegener; Iain D. Campbell; Jari Ylänne; David A. Calderwood


Book ID
116754109
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
555 KB
Volume
21
Category
Article
ISSN
1097-2765

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✍ Wolfgang H. Goldmann 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 82 KB

Actin‐binding protein (ABP‐280; filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can cross‐link actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a