✦ LIBER ✦
PHOSPHORYLATION OF FILAMIN (ABP-280) REGULATES THE BINDING TO THE LIPID MEMBRANE, INTEGRIN, AND ACTIN
✍ Scribed by Wolfgang H. Goldmann
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 82 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
Actin‐binding protein (ABP‐280; filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can cross‐link actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a substrate for p56^lck^, a lymphocyte‐specific member of the src family of protein tyrosine kinases associated with cell surface glycoproteins is considered. The results suggest conformationally‐induced regulation of filamin (ABP‐280).