✦ LIBER ✦

The molecular basis for HLA class II associations with rheumatoid arthritis

✍ Scribed by Gerald T. Nepom; John A. Hansen; Barbara S. Nepom

Publisher: Springer
Year: 1987
Tongue: English
Weight: 893 KB
Volume: 7
Category: Article
ISSN: 0271-9142
DOI: 10.1007/bf00915418

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Molecular basis for the association betw

Molecular basis for the association between HLA DR4 and rheumatoid arthritis. From the shared epitope hypothesis to a peptidic model of rheumatoid arthritis

✍ Salvatore Albani; Jean Roudier 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 354 KB

Susceptibility to rheumatoid arthritis (RA) maps to residues QKRAA/QRRAA in the third hypervariable region of the HLA DRI31 chain. Peptides from the same area of MHC class II molecules are able to modulate the T-cell repertoire by deleting self-reactive T-cells. The Epstein Barr virus glycoprotein g

Differential expression of HLA class II

Differential expression of HLA class II genes associated with disease susceptibility and progression in rheumatoid arthritis

✍ Christian Heldt; Joachim Listing; Osman Sözeri; Franca Bläsing; Stefan Frischbut 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB 👁 2 views

Class I associations and frequencies of

Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis

✍ H. I. Brunner; E. Ivaskova; J. P. Haas; A. Andreas; E. Keller; J. Hoza; S. Havel 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 541 KB

A total of 94 patients with juvenile chronic arthritis (JCA) was tested for HLA class I by serology and for class II by RFLP typing. Early onset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males and females. The combination (joint occurrence) of these JCA associated alleles (A2, DR5, D

Early and aggressive treatment of rheuma

Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage

✍ L. R. Lard; M. Boers; A. Verhoeven; K. Vos; H. Visser; J. M. W. Hazes; A. H. Zwi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

## Abstract ## Objective The presence of certain HLA class II antigens is strongly associated with the progression of joint destruction in rheumatoid arthritis (RA). Such antigens may be more effective than other class II antigens in inducing the formation of autoreactive T cells after presentatio

Association between HLA class II genes a

Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis

✍ Floris A. Van Gaalen; Jill Van Aken; Tom W. J. Huizinga; Geziena M. Th. Schreude 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 2 views

## Abstract ## Objective The functional role of HLA class II molecules in the pathogenesis of rheumatoid arthritis (RA) is unclear. HLA class II molecules are involved in the interaction between T and B lymphocytes required for long‐lived B cell responses and generation of high‐affinity IgG antibo

Molecular analysis of HLA class II assoc

Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness

✍ Andrew Godkin; Miles Davenport; Adrian V.S. Hill 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

Clearance of acute hepatitis B virus (HBV) infection is associated with a vigorous CD4+ T-cell response focusing on the core protein. HLA class II glycoproteins present viral peptides to CD4+ T cells and influence the immune responses. HLA-DRB1\*1301/2 have been associated with viral clearance, and