## Abstract ## Objective To prospectively investigate the effect of the DERAA‐encoding HLA alleles on disease susceptibility and severity in a large cohort of patients with rheumatoid arthritis (RA), and to differentiate protective effects from nonpredisposition by comparing subgroups of patients
Differential expression of HLA class II genes associated with disease susceptibility and progression in rheumatoid arthritis
✍ Scribed by Christian Heldt; Joachim Listing; Osman Sözeri; Franca Bläsing; Stefan Frischbutter; Brigitte Müller
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 145 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective The presence of certain HLA class II antigens is strongly associated with the progression of joint destruction in rheumatoid arthritis (RA). Such antigens may be more effective than other class II antigens in inducing the formation of autoreactive T cells after presentatio
## Abstract ## Objective The functional role of HLA class II molecules in the pathogenesis of rheumatoid arthritis (RA) is unclear. HLA class II molecules are involved in the interaction between T and B lymphocytes required for long‐lived B cell responses and generation of high‐affinity IgG antibo