The mode of inheritance in essential familial hypercholesterolemia
โ Scribed by Kurt Hirschhorn; Charles F. Wilkinson Jr.
- Book ID
- 115674831
- Publisher
- Elsevier Science
- Year
- 1959
- Tongue
- English
- Weight
- 680 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1555-7162
No coin nor oath required. For personal study only.
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## Abstract A positive family history is present in many patients with essential tremor (ET), but twin studies and segregation analysis have suggested that ET is not entirely a genetic disorder. Two genetic loci have been identified in autosomal dominant (AD) ET and polymorphisms in the __DRD3__ an
Sib-pair linkage analysis was used to screen a large pedigree, ascertained through four members with hypercholesterolemia, for evidence of linkage between 12 quantitative traits and 15 genetic marker loci. Traits were analyzed on the untransformed, natural log and square root-transformed scales. Aft