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Linkage analysis in a large pedigree ascertained due to essential familial hypercholesterolemia

✍ Scribed by Dr. Joan E. Bailey-Wilson; Alexander F. Wilson; Vaneeta Bamba

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
313 KB
Volume
10
Category
Article
ISSN
0741-0395

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✦ Synopsis

Sib-pair linkage analysis was used to screen a large pedigree, ascertained through four members with hypercholesterolemia, for evidence of linkage between 12 quantitative traits and 15 genetic marker loci. Traits were analyzed on the untransformed, natural log and square root-transformed scales. After adjusting for multiple tests, there is a suggestion of linkage between height and the Kidd blood group on chromosome 18 and between VLDL cholesterol, and possibly triglyceride, and KM on chromosome 2. cD 1993 Wiley-Liss, Inc.

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