The mitotic origin of chromosomal instability
โ Scribed by Bakhoum, Samuel F.; Silkworth, William T.; Nardi, Isaac K.; Nicholson, Joshua M.; Compton, Duane A.; Cimini, Daniela
- Book ID
- 121771449
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 223 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0960-9822
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The origin of mitotic cells was investigated histologically in chorionic tissue, metaphase plates of which were used for direct cytogenetic study. Mitotic figures were often observed in the Langhans' cell layers, but absolutely none were seen in the syncytium and stromal cells.
An unusual structural rearrangement of the Y chromosome resulting in seven different cell lines was found in a male infant with coronal synostosis as the only major clinical symptom. At least three different events must have occurred to explain the patient's karyotype: nondisjunction, chromosome bre