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Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer

โœ Scribed by Jeffrey L. Salisbury; Antonino B. D'Assoro; Wilma L. Lingle


Book ID
111593739
Publisher
Springer US
Year
2004
Tongue
English
Weight
210 KB
Volume
9
Category
Article
ISSN
1083-3021

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Over-expression of a centrosomal serine/threonine kinase, STK15/BTAK, induces centrosome amplification, which results in chromosomal instability (CIN) in cell culture. In the present study, we investigated the correlation of STK15/BTAK mRNA expression with CIN and various clinicopathological factors