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The mitogenic effect of A23187 in human peripheral lymphocytes

✍ Scribed by Jensen, Pamela; Winger, Larry; Rasmussen, Howard; Nowell, Peter

Book ID
122640746
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
625 KB
Volume
496
Category
Article
ISSN
0304-4165

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Direct mitogenic effect of ionophore A23
Direct mitogenic effect of ionophore A23187 on isolated human T helper lymphocytes
✍ Karl E. O. Γ…kerman; Leif C. Andersson πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 297 KB

The Ca2+ ionophore A23187 induces only a weak mitogenic response in cultures of unfractionated mononuclear leukocytes from human blood. When a comitogen, 12-O-tetradecanoyl-phorbol-13-acetate, which by itself is nonmitogenic, is added, a greatly increased cell proliferation is obtained. Highly purif