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The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver

✍ Scribed by Juan J Dı́az-Gil; Pedro L Majano; Manuel López-Cabrera; Vicente Sánchez-López; Carmen Rúa; Celia Machı́n; Carolina Trilla; Rafael Garcı́a-Cañero; Ricardo Moreno-Otero


Book ID
118565930
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
521 KB
Volume
38
Category
Article
ISSN
0168-8278

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Hepatocyte growth factor and transforming growth factor-a are two well-known hepatomitogens for primary hepatocyte cultures. Here we report that these two growth factors also stimulate in uiuo DNA syntheses in normal, unoperated, adult rat liver after 24-hr continuous intraportal infusion. As determ