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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase

✍ Scribed by Yang, Qin; Zhang, Ran; Wang, Xin W; Linke, Steven P; Sengupta, Sagar; Hickson, Ian D; Pedrazzi, Graziella; Perrera, Claudia; Stagljar, Igor; Littman, Susan J


Book ID
110068538
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
385 KB
Volume
23
Category
Article
ISSN
0950-9232

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Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O 6 position of guanine. These methyl adducts are removed from DNA by the O 6 -alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O 6 -methylguanine (O 6 meG) induces cell death in OGAT-d