The microwave-assisted synthesis of a 2-carboxyphosphole

✍ Scribed by Steven van Zutphen; Guilhem Mora; Vicente J. Margarit; Xavier F. Le Goff; Duncan Carmichael; Pascal Le Floch

• Book ID: 104095005
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 135 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.01.075

✦ Synopsis

Using a one-pot four-step reaction a readily available phospholide was converted efficiently to a 2-carboxyphosphole. This compound can be used as a building block for the synthesis of phosphole-containing peptides, where the phosphole can serve as a coordination site for late transition metals and may affect the secondary structure of the peptide.