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Microwave-assisted synthesis of a [3+2] cycloaddition library

✍ Scribed by Noel S Wilson; Christopher R Sarko; Gregory P Roth

Book ID
104232031
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
54 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel method for the synthesis of a library of substituted prolines utilizing microwave-assisted synthesis is described. The process involves rapid microwave irradiation of a-aminoesters and aldehydes to generate imines followed by the addition of a dipolarophile and subsequent irradiation to produce the [3+2] cycloadducts. The decrease in reaction time afforded by microwave irradiation allowed for the production of an 800-membered solution-phase library in twofold less time than by traditional thermal methods. These products were purified by solid-supported reagent scavenging to furnish the desired products in high yields and purity.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Microwave-Assisted
ChemInform Abstract: Microwave-Assisted Synthesis of a [3 + 2] Cycloaddition Library.
✍ Noel S. Wilson; Christopher R. Sarko; Gregory P. Roth πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Microwave-Assisted [3 + 2] Cycloaddition
Microwave-Assisted [3 + 2] Cycloadditions of Azomethine Ylides.
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## Abstract For Abstract see ChemInform Abstract in Full Text.