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The microglial gene regulatory network activated by interferon-gamma

โœ Scribed by Linda B. Moran; Dawn C. Duke; Manuel B. Graeber

Book ID
118475651
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
689 KB
Volume
183
Category
Article
ISSN
0165-5728

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Activation of microglial cells occurs during the pathogenesis of various neurologic diseases. However, the mechanisms of activation in vivo are still elusive. We infused adult rats intravenously with interferon-g and demonstrated microglial cell activation after three days of treatment. We show for