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Activation of microglial and endothelial cells in the rat brain after treatment with interferon-gamma in vivo

✍ Scribed by Veronika Grau; Birgit Herbst; Peter H. Van der Meide; Birte Steiniger

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
108 KB
Volume
19
Category
Article
ISSN
0894-1491

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✦ Synopsis

Activation of microglial cells occurs during the pathogenesis of various neurologic diseases. However, the mechanisms of activation in vivo are still elusive. We infused adult rats intravenously with interferon-g and demonstrated microglial cell activation after three days of treatment. We show for the first time that microglial cells proliferate inside the brain in response to a circulating cytokine. Microglial cells were induced to express major histocompatibility (MHC) class I and class II antigens and small amounts of leukocyte function-associated molecule 1 (LFA-1, CD11a). On endothelial cells of the brain, MHC class I and class II antigens and intercellular adhesion molecule 1 (ICAM-1, CD54) were enhanced.

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