The Michael reaction of acetophenones with trans-dibenzoylethylene

✍ Scribed by Mohammad M Al-Arab; Mohammad A Atfeh; Fowzia S Al-Saleh

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 477 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01028-9

✦ Synopsis

The synthesis of a series of highly substituted cyclohexane derivatives has been carried out in a single one-pot reaction of acetophenones and lrnfl.s-dibenzoylethylene (12) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 4-aroyl-2,3,5tribenzoyl-I-phenylcyclohexanols A structural assignments was achieved from the elemental analysis, infrared, and proton nuclear magnetic resonance spectroscopy. The single crystal x-ray crystallography clearly shows the highly substituted cyclohexane ring.