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The Metabolite of 3',5'-Dichloro-4-amino-4-deoxy-N 10 -methylpteroylglutamic Acid (Dichloromethotrexate)

✍ Scribed by Li Loo, Ti; Adamson, Richard H.


Book ID
126964091
Publisher
American Chemical Society
Year
1965
Tongue
English
Weight
426 KB
Volume
8
Category
Article
ISSN
0022-2623

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Metabolite of 4-amino-4-deoxy-N10-methyl
✍ David G. Johns; Ti Li Loo πŸ“‚ Article πŸ“… 1967 πŸ› John Wiley and Sons 🌐 English βš– 417 KB

Amin0-4-deoxy-N'~-methylpteroylglutamic acid (methotrexate; M T X ) is rapidly metabolized by rabbit liver aldehyde oxidase. The MTX metabolite, on oxidative cleavage with permanganate, yields a simple pteridine having the spectrophotometric and chromatographic properties of 2,4-diamino-7-hydroxy-G-