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The metabolism of tritiated thioacetamide in the rat

✍ Scribed by K. R. Rees; G. F. Rowland; J. S. Varcoe


Publisher
John Wiley and Sons
Year
1966
Tongue
French
Weight
700 KB
Volume
1
Category
Article
ISSN
0020-7136

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✦ Synopsis


A method is described for preparing tritiated thioacetamide. Thi~acetamide-~H was fed daily to rats at a level which is known to produce liver tumours after six months' feeding. It was shown that less than I % was excreted


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Hepatic mitochondrial functions related to fatty acid metabolism, including the respiratory control ratio, fatty acid oxidative capacity and carnitine palmitoyltransferase I activity, were studied in vitro with mitochondria isolated from rats treated with thioacetamide for up to 12 wk. The levels of