The metabolism of dopamine in the blood of ruminant animals: Formation of 3,4-dihydroxyphenylacetaldehyde
β Scribed by D.F. Sharman
- Book ID
- 113379428
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 638 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0306-4492
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π SIMILAR VOLUMES
3,4-Dihydroxyphenylacetaldehyde (DOPAL) has been reported to be a toxic metabolite formed by the oxidativedeamination of dopamine (DA) catalyzed by monoamine oxidase. This aldehyde is either oxidized to 3,4dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase, an NAD-dependent enzyme or reduc
We recently described the chemical synthesis of 3, 4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde, the monamine oxidase metabolites of dopamine and noradrenaline, respectively. We demonstrated the neurotoxicity of these compounds. Catecholamine nerve cells which synthesize these