The Menkes protein : an example of copper transport and protein trafficking in mammals.
β Scribed by M.C. Pascale; S. Franceschelli; O. Moltedo; A. Leone
- Book ID
- 114362485
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 92 KB
- Volume
- 126
- Category
- Article
- ISSN
- 1095-6433
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π SIMILAR VOLUMES
Menkes disease is an X-linked, recessive disorder of copper metabolism that occurs in approximately 1 in 200,000 live births. The condition is characterized by skeletal abnormalities, severe mental retardation, neurologic degeneration, and patient mortality in early childhood. The symptoms of Menkes
## Abstract Proteins of approximately 10,000 daltons (presumably metallothionein) and greater than 75,000 daltons bound ^64^Cu when this metal was added to fibroblast lysates. Treatment with either 2βmercaptoethanol or the disodium salt of ethylenediamine tetraacetic acid demonstrated that the high