𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Investigation of the copper binding sites in the Menkes disease protein, ATP7A

✍ Scribed by P. Y. Jensen; N. Bonander; B. G. Karlsson; N. Horn; Z. Tümer; O. Farver

Book ID
110222834
Publisher
Springer
Year
1998
Tongue
English
Weight
168 KB
Volume
21
Category
Article
ISSN
0141-8955

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Molecular mechanisms of copper metabolis
Molecular mechanisms of copper metabolism and the role of the Menkes disease protein
✍ Mark D. Harrison; Charles T. Dameron 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB 👁 1 views

Menkes disease is an X-linked, recessive disorder of copper metabolism that occurs in approximately 1 in 200,000 live births. The condition is characterized by skeletal abnormalities, severe mental retardation, neurologic degeneration, and patient mortality in early childhood. The symptoms of Menkes

Sequence variation in the ATP-binding do
Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system
✍ Gloria Hsi; Lara M. Cullen; Georgina Macintyre; Matthew M. Chen; D. Moira Glerum 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB 👁 1 views

ATP7B is a copper transporting P-type ATPase defective in the autosomal recessive copper storage disorder, Wilson disease (WND). Functional assessment of variants helps to distinguish normal from disease-causing variants and provides information on important amino acid residues. A total of 11 missen

Studies of the copper-binding proteins i
Studies of the copper-binding proteins in Menkes and normal cultured skin fibroblast lysates
✍ Gundula U. LaBadie; Nicholas G. Beratis; Peter M. Price; Kurt Hirschhorn 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 523 KB

## Abstract Proteins of approximately 10,000 daltons (presumably metallothionein) and greater than 75,000 daltons bound ^64^Cu when this metal was added to fibroblast lysates. Treatment with either 2‐mercaptoethanol or the disodium salt of ethylenediamine tetraacetic acid demonstrated that the high