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The membranes’ role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation

✍ Scribed by Ana Salomé Veiga; Miguel A.R.B. Castanho


Book ID
113457284
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
171 KB
Volume
71
Category
Article
ISSN
0166-3542

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The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (␤clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the